SOT ToxExpo 2025

Reverse Engineering of Pharmaceuticals

Reverse engineering projects yield data regarding API & excipients for the development of generic formulations & resolving legal challenges.

The TOF-SIMS spectrum of the droplets showing peaks in the mass range from 320-500u is shown in the top figure, while the bottom figure is from a control region on the surface. The droplets were determined to be pentaerithrytol tetraoctanoate.

Organic Contamination on Surfaces

Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) detects organic contamination on surfaces of semiconductors.

GDMS Webinar

In the full webinar we will focus on full survey chemical analysis using solid sampling high resolution GDMS.

30keV Scanning Transmission Electron Microscopy

30keV Scanning Transmission Electron Microscopy (STEM) can provide 3Å resolution bright field (BF) and dark field (DF, ADF, HAADF) images

Figure 1 Schematic of PE-EAA – PE laminate showing failure location.

Root Cause Determination of Adhesion Failure in Medical Device Packaging

XPS and TOF-SIMS to solve adhesive failure of a polyethylene-ethylene acrylic acid (co-polymer) heat seal to polyethylene in a medical device.

EAG supports development of generic drugs

Materials Characterization for Pharmaceuticals

Materials Characterization for Pharmaceuticals EAG has been contacted by pharmaceutical companies to characterize materials and chemistries where the measurements are challenging. We have developed methods for determining API morphology and